![]() Although the exact mechanisms of action are not completely understood, it is established that stimulation of primary afferent (PA) mechanosensory fibres produces pain relief in patients with chronic neuropathic pain ( Sdrulla et al., 2018). Spinal cord stimulation (SCS) is a widely-used therapy for chronic pain management with a proven track record of efficacy and a favourable safety profile compared to pharmacological therapies ( Kapural et al., 2015 North et al., 2016 Deer et al., 2018 Thomson et al., 2018 Mekhail et al., 2019 Russo et al., 2020). Identification of PSDC fibre activation in humans emphasises the need for further investigation into the role they play in pain relief and the sensory response sensation (paraesthesia) experienced by patients undergoing SCS. A clear difference in conduction velocities between the primary afferents and the PSDC fibres were observed. Synaptic activation occurred in 9 of the 14 patients analysed and depended on the vertebral level of stimulation. Our investigation in humans with chronic neuropathic pain undergoing SCS therapy, found that post-synaptic dorsal column (PSDC) fibres can be activated synaptically by the primary afferents recruited by stimulation, and axonically by the stimulation pulses directly. While the efficacy of SCS has been demonstrated, the precise mechanism of action and nature of the fibres activated by stimulation remain largely unexplored. Spinal cord stimulation (SCS) treatment for chronic pain relies on the activation of primary sensory fibres ascending to the brain in the dorsal columns. Thomas’ NHS Foundation Trust, London, United Kingdom 1Saluda Medical, Macquarie Park, NSW, Australia.Gerrit Eduard Gmel 1 * † Rosana Santos Escapa 1 Teddy Edmond Benkohen 1 Dave Mugan 1 John Louis Parker 1 Stefano Palmisani 2
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